| AT-7519(HCI) |
| 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-Pyrazole-3-carboxamide hydrochloride |
| (CAS 902135-91-5) |
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| Description： |
AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; is less potent to CDK3 and little active to CDK7.
in vivo: A twice daily dosing of AT7519 (9.1 mg/kg) causes tumor regression of both early-stage and advanced-stage s.c. tumors in the HCT116 and HT29 colon cancer xenograft models. AT7519 treatment (15 mg/kg) inhibits tumor growth and prolongs the median overall survival of mice in the human MM xenograft mouse model in association with increased caspase 3 activation.
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| Product No. |
KT00111 |
| Product Name |
AT-7519(HCI) |
| Synonyms |
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| Formal Name |
4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-Pyrazole-3-carboxamide hydrochloride |
| CAS Number |
902135-91-5 |
| Molecular Formula |
C16H17Cl2N5O2•HCl |
| Formula Weight |
418.7 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
AMG 925
AT7519
AZD-5438
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BMS-265246
BS-181
CDK-IN-2
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