| AST-487 |
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| (CAS 630124-46-8) |
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| Description： |
AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. NVP-AST487 has an IC(50) of 0.88 mumol/L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. NVP-AST487 induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice. NVP-AST487 inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription.
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| Product No. |
KT00104 |
| Product Name |
AST-487 |
| Synonyms |
NVP-AST 487 |
| Formal Name |
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| CAS Number |
630124-46-8 |
| Molecular Formula |
C26H30F3N7O2 |
| Formula Weight |
529.56 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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