| Flutamide |
| 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide |
| (CAS 13311-84-7) |
 |
| Description： |
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
Target: androgen receptor
in vitro: Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. lutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.
in vivo: Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity. |
| Product No. |
KT20509 |
| Product Name |
Flutamide |
| Synonyms |
SCH 13521; Eulexin; Flutamin; Drogenil |
| Formal Name |
2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide |
| CAS Number |
13311-84-7 |
| Molecular Formula |
C11H11F3N2O3 |
| Formula Weight |
276.21 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. $100/25g |
|
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BIO |
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