| Deltarasin hydrochloride |
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| (CAS 1440898-82-7) |
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| Description： |
Deltarasin Hcl is a novel and small molecule inhibitor which can inhibit the KRAS-PDEδ interaction(Kd= 41 nM. binding to PDEδ) and impairs oncogenic KRAS signalling.
IC50 Value: 41±12 nM (binding to PDEδ in cell)
Target: KRAS-PDEδ interaction
Interfering with binding of mammalian PDEδ to KRAS by means of small molecules provides a novel opportunity to suppress oncogenic RAS signalling by altering its localization to endomembranes. Biochemical screening and subsequent structure-based hit optimization yielded inhibitors of the KRAS-PDEδ interaction that selectively bind to the prenyl-binding pocket of PDEδ with nanomolar affinity, inhibit oncogenic RAS signalling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
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| Product No. |
KT20466 |
| Product Name |
Deltarasin hydrochloride |
| Synonyms |
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| Formal Name |
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| CAS Number |
1440898-82-7 |
| Molecular Formula |
C40H38ClN5O |
| Formula Weight |
640.22 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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