| Cilomilast |
| 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclohexane-1-carboxylic acid |
| (CAS 153259-65-5) |
 |
| Description： |
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
IC50 value: 110 nM
Target: PDE 4
Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.
|
| Product No. |
KT20463 |
| Product Name |
Cilomilast |
| Synonyms |
SB-207499; Ariflo; SB207499; SB 207499 |
| Formal Name |
4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclohexane-1-carboxylic acid |
| CAS Number |
153259-65-5 |
| Molecular Formula |
C20H25NO4 |
| Formula Weight |
343.42 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
PDE
Cilostazol
Deltarasin
Diphylline
GSK256066
IBMX
Ibudilast
Milrinone
Mirodenafil
Nortadalafil
Oglemilast
Olprinone
|
|
