| (R)-(-)-Rolipram |
| (R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| (CAS 85416-75-7) |
 |
| Description： |
(R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4.
IC50 value:
Target: PDE4
in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 +/- 0.09 microM) in enhancing isoprenaline (10 microM)-stimulated cyclic AMP accumulation. Rolipram was a relatively weak inhibitor of partially purified pig aortic PDE IV and only slight stereospecificity was exhibited [IC50 (-)-rolipram = 1.47 +/- 0.09 microM; IC50 (+)-rolipram = 2.73 +/- 0.38 microM]. The IC50 of rolipram (racemate) of these two fractions was 492 and 79 nM, respectively. The R-(-)-enantiomer of rolipram inhibited the cAMP-phosphodiesterase activity in the latter fraction 10 times more than did S-(+)-rolipram, and the inhibition of the former fraction was less stereospecific.
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| Product No. |
KT20457 |
| Product Name |
(R)-(-)-Rolipram |
| Synonyms |
(R)-Rolipram; (-)-Rolipram |
| Formal Name |
(R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one |
| CAS Number |
85416-75-7 |
| Molecular Formula |
C16H21NO3 |
| Formula Weight |
275.34 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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