| PF-670462 |
| 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride |
| (CAS 950912-80-8) |
 |
| Description： |
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines.PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively).It less effectively inhibits a wide variety of related or common kinases.Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals.It also blocks the locomotor response to amphetamines in mice.
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| Product No. |
KT00685 |
| Product Name |
PF-670462 |
| Synonyms |
PF 670462; PF670462 |
| Formal Name |
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride |
| CAS Number |
950912-80-8 |
| Molecular Formula |
C19H20FN5.2(HCl) |
| Formula Weight |
410.32 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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