| Pifithrin-α |
| 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide |
| (CAS 63208-82-2) |
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| Description： |
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM.Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.
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| Product No. |
KT00698 |
| Product Name |
Pifithrin-α |
| Synonyms |
PFT-α;Pifithrin-alpha;Pifithrin |
| Formal Name |
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide |
| CAS Number |
63208-82-2 |
| Molecular Formula |
C16H18N2OS.HBr |
| Formula Weight |
367.30 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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