| PQ401 |
| N-(5-Chloro-2-methoxyphenyl)-N’-(2-methyl-4-quinolinyl)-urea |
| (CAS 196868-63-0) |
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| Description： |
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.
PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
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| Product No. |
KT00720 |
| Product Name |
PQ401 |
| Synonyms |
PQ 401; PQ-401 |
| Formal Name |
N-(5-Chloro-2-methoxyphenyl)-N’-(2-methyl-4-quinolinyl)-urea |
| CAS Number |
196868-63-0 |
| Molecular Formula |
C18H16ClN3O2 |
| Formula Weight |
341.79 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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