| A-803467 |
| 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
| (CAS 944261-79-4) |
 |
| Description： |
Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. |
| Product No. |
KT00017 |
| Product Name |
A-803467 |
| Synonyms |
|
| Formal Name |
5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide |
| CAS Number |
944261-79-4 |
| Molecular Formula |
C19H16ClNO4 |
| Formula Weight |
357.8 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
1 year |
| Storage |
-20℃ |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500. |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
Bupivacaine
QX-314 (bromide)
AG1024
SPP-301
AG-490 |
|
