| Irsogladine maleate |
| 2,4-Diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate |
| (CAS 84504-69-8) |
 |
| Description： |
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
Target: PDE4; mACHR
Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions.
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| Product No. |
KT20430 |
| Product Name |
Irsogladine maleate |
| Synonyms |
Dicloguamine maleate; MN1695 |
| Formal Name |
2,4-Diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate |
| CAS Number |
84504-69-8 |
| Molecular Formula |
C13H11Cl2N5O4 |
| Formula Weight |
372.16 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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