| MK0966 |
| 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone |
| (CAS 162011-90-7) |
 |
| Description： |
Rofecoxib is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 activity with 1,000-fold selectivity over that of COX-1 (IC50s = 26 nM and > 50 µM in human osteosarcoma cells). In in vivo rodent models, rofecoxib can inhibit carrageenan-induced paw edema (ID50 = 1.5 mg/kg), carrageenan-induced paw hyperalgesia (ID50 = 1.0 mg/kg), lipopolysaccharide-induced pyresis (ID50 = 0.24 mg/kg), and adjuvant-induced arthritis (ID50 = 0.74 mg/kg/day). Despite its effectiveness against pain and inflammation, rofecoxib was removed from the market in 2004 due to concerns over its long-term cardiovascular safety.
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| Product No. |
KT00561 |
| Product Name |
MK0966 |
| Synonyms |
Vioxx;Rofecoxib |
| Formal Name |
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone |
| CAS Number |
162011-90-7 |
| Molecular Formula |
C17H14O4S |
| Formula Weight |
314.4 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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