| Miltefosine |
| Ethanaminium, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt |
| (CAS 58066-85-6) |
 |
| Description： |
Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effective against both promastigotes and amastigotes.
Miltefosine is an inhibitor of CTP:phosphocholine cytidylyl transferase and has antimetastatic properties. At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively. The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Treatment of cells with 25 µM miltefosine results in a 53% increase in ceramide concentration relative to control. Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), although the mechanism of this antiprotozoal activity is also poorly understood. |
| Product No. |
KT00553 |
| Product Name |
Miltefosine |
| Synonyms |
HePC; Impavido; Miltex; Hexadecyl phosphocholine |
| Formal Name |
Ethanaminium, 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt |
| CAS Number |
58066-85-6 |
| Molecular Formula |
C21H46NO4P |
| Formula Weight |
407.57 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
VE-822
WZ4003
AZD5363
A-674563
Triciribine
GSK690693
Ipatasertib (GDC-0068) |
|
