| Abiraterone acetate |
| (3β)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol, acetate ester |
| (CAS 154229-18-2) |
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| Description： |
The cytochrome P450 (CYP) isoform CYP17A1 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Abiraterone acetate blocks CYP17A1 by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (IC50 = 18 and 17 nM, respectively).In mice as well as men, it essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone.It improves radiographic progression-free survival and significantly delays decline in human metastatic castration-resistant prostate cancer.
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| Product No. |
KT20060 |
| Product Name |
Abiraterone acetate |
| Synonyms |
CB-7630; CB7630; CB 7630 |
| Formal Name |
(3β)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol, acetate ester |
| CAS Number |
154229-18-2 |
| Molecular Formula |
C26H33NO2 |
| Formula Weight |
391.6 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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