| LY2835219 |
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| (CAS 1231930-82-7) |
 |
| Description： |
LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM, respectively.
in vivo: LY2835219 saturates BBB efflux with an unbound plasma IC50 of about 95 nM. The percent of dose in brain for LY2835219-MsOH is 0.5–3.9%. In both a subcutaneous and intracranial human glioblastoma model (U87MG), LY2835219-MsOH suppressed tumor growth in a dose-dependent manner both as a single agent, and in combination with temozolomide.
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| Product No. |
KT00525 |
| Product Name |
LY2835219 |
| Synonyms |
ABEMACICLIB; CDK4/6 dual inhibitor |
| Formal Name |
|
| CAS Number |
1231930-82-7 |
| Molecular Formula |
C28H36F2N8O3S |
| Formula Weight |
602.7 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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