| LY293111 |
| 2-[3-[3-[(5-ethyl-4’-fluoro-2-hydroxy[1,1’-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid |
| (CAS 161172-51-6) |
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| Description： |
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. LY293111 is a potent antagonist of the leukotriene B4 (LTB4) receptor, BLT1, that inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 17.6 nM and inhibits the LTB4-induced chemotaxis of human neutrophils with an IC50 value of 6.3 nM. LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 human pancreatic cancer cells in vitro (250-1,000 nM) and subcutaneous xenografts in athymic mice (250 mg/kg/day), inducing apoptosis and S-phase arrest.
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| Product No. |
KT00510 |
| Product Name |
LY293111 |
| Synonyms |
VML 295,Etalocib |
| Formal Name |
2-[3-[3-[(5-ethyl-4’-fluoro-2-hydroxy[1,1’-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid |
| CAS Number |
161172-51-6 |
| Molecular Formula |
C33H33FO6 |
| Formula Weight |
543.6 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
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