| Temsirolimus |
| 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate] rapamycin |
| (CAS 162635-04-3) |
 |
| Description： |
Rapamycin (Item No. 13346) is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin. Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF. Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.
|
| Product No. |
KT20059 |
| Product Name |
Temsirolimus |
| Synonyms |
Torisel; CCI-779; CCI 779; CCI779 |
| Formal Name |
42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate] rapamycin |
| CAS Number |
162635-04-3 |
| Molecular Formula |
C56H87NO16 |
| Formula Weight |
1030.3 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
AZD-8055
AZD2-14
BEZ235
Doforolimus
Everolimus
GSK1059615
GSK2126458
LY 202511
OSI-027
Torin 1
Torin 2
XL388
|
|
