Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Target: Glucocorticoid Receptor
Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced.

Glucocorticoid Receptor
Desonide
Dexamethasone
Fluocinolone Acetonide
Fluocinonide
Fluticasone propionate
Glucocorticoid receptor agonist
Hydrocortisone
Loteprednol Etabonate
Meprednisone
Methylprednisolone
Mometasone furoate
Prednisolone
Triamcinolone