| LX1606 |
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| (CAS 1033805-22-9) |
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| Description： |
LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
in vivo: LX1606 (LX 1606, LX-1606) is useful for Neurological Diseas. LX1606 were given orally to mice. LX1606 reduced 5-HT significantly in the gut and blood but not in the brain. oral LX1032 reduced the severity of TNBS-induced colitis; the expression of 24% of 84 genes encoding inflammation-related cytokines and chemokines was lowered at least fourfold and the reduced expression of 17% was statistically significant. Treatment with LX1606 showed a strong positive effect in ameliorating TNBS-induced IBD in mice as assessed by various parameters of disease development. These preclinical data demonstrate that inhibition of TPH activity by LX1606 may provide a new approach for the treatment of IBD and its serotonin-mediated symptoms.
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| Product No. |
KT00504 |
| Product Name |
LX1606 |
| Synonyms |
Telotristat ethyl |
| Formal Name |
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| CAS Number |
1033805-22-9 |
| Molecular Formula |
C27H26ClF3N6O3 |
| Formula Weight |
574.98 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
LX-1031
LX1606 Hippurate
Telotristat
DMOG
AGI-6780
LB42708
Isotretinoin
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