Dexamethasone(MK 125; NSC 34521; Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties.
IC50 Value: 58 nM (HECM-induced eosinophil survival)
Target:
in vitro: DEX in concentrations from 1 to 100μM did not change LDH release but exposure to 10μM and 100μM DEX for 24, 48 and 72h caused a significant reduction in cell viability and proliferation as confirmed by MTT reduction and BrdU ELISA assays, respectively. Dex impaired neuron and oligodendrocyte maturation in PUFA-supplemented cells, demonstrated by the reduction of neurite lengths and oligodendrocyte sizes.
in vivo: The levels of IL-17, IL-6 and Tim-3 were substantially increased and the IL-10 level decreased in BALF in the asthmatic mice, which was significantly reversed by DEX treatment.  An IM bolus injection of DEX sodium phosphate in pigs resulted in a fast and complete absorption, with a mean maximal plasma concentration of 80.94±21.29ng/mL at 0.35±0.21h and a high absolute bioavailability of 131.06±26.05%.
Clinical trial: PANORAMA-1: Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma. Phase 3

Glucocorticoid Receptor
Desonide
Fluocinolone Acetonide
Fluocinonide
Fluticasone propionate
Glucocorticoid receptor agonist
Hydrocortisone
Loteprednol Etabonate
Meprednisone
Methylprednisolone
Mometasone furoate
Prednisolone
Triamcinolone