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Fluvastatin 
7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
(CAS 93957-54-1)
Description:

Fluvastatin (Leschol) inhibits HMG-CoA reductase activity with IC50 of 8 nM.
IC50 value: 8 nM
Target: HMG-CoA reductase
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

 

Product No. KT20369 
Product Name Fluvastatin 
Synonyms Leschol
Formal Name 7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
CAS Number 93957-54-1
Molecular Formula C24H26FNO4
Formula Weight 411.47
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
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