| YM155 |
| 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide |
| (CAS 781661-94-7) |
 |
| Description： |
Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.At concentrations up to 100 nM, YM155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.YM155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer. |
| Product No. |
KT01007 |
| Product Name |
YM155 |
| Synonyms |
Sepantronium bromide |
| Formal Name |
4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide |
| CAS Number |
781661-94-7 |
| Molecular Formula |
C20H19N4O3.Br |
| Formula Weight |
443.30 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
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