| KRX-0401 |
| 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt |
| (CAS 157716-52-4) |
 |
| Description： |
Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5µM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
|
| Product No. |
KT00484 |
| Product Name |
KRX-0401 |
| Synonyms |
|
| Formal Name |
4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt |
| CAS Number |
157716-52-4 |
| Molecular Formula |
C25H53NO4P |
| Formula Weight |
462.7 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
3CAI
A-443654
A-674563
Afuresertib
AKT inhibitor VIII
AT13148
AT7867
AZD5363
CCT128930
GDC-0068
GSK-690693
|
|
