| Roflumilast |
| 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide |
| (CAS 162401-32-3) |
 |
| Description： |
Roflumilast is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.
Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP.Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D).It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM.Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.
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| Product No. |
KT00773 |
| Product Name |
Roflumilast |
| Synonyms |
B 9302-107;BY 217;Daxas;BYK 20869 |
| Formal Name |
3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide |
| CAS Number |
162401-32-3 |
| Molecular Formula |
C17H14Cl2F2N2O3 |
| Formula Weight |
403.21 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
CP 80633
IBMX
Ibudilast
ML-030
Rolipram
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