| KB-R7943 |
| 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester carbamimidothioic acid, monomethanesulfonate |
| (CAS 182004-65-5) |
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| Description： |
The Na+/Ca2+ exchanger (NCX) is a major regulator of intracellular calcium concentration that is largely expressed in cardiac sarcolemma (NCX1) but also in brain and skeletal muscle (NCX2). KB-R7943 is an isothiourea derivative that selectively inhibits the reverse mode of NCX1 (IC50 = 1.2-2.4 µM), preventing intracellular sodium-dependent calcium uptake in whole cells. It is much less potent at preventing extracellular sodium-dependent calcium efflux from intact cells (IC50 > 30 µM). In cultured hippocampal neurons, KB-R7943 exhibits neuroprotection from glutamate-induced excitotoxicity by blocking NMDA receptor-mediated activity (IC50 = 13.4 µM) and inhibiting complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM). KB-R7943 has also been shown to block transient receptor potential canonical channels, which are important mediators of calcium-dependent signal transduction.
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| Product No. |
KT00476 |
| Product Name |
KB-R7943 |
| Synonyms |
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| Formal Name |
2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester carbamimidothioic acid, monomethanesulfonate |
| CAS Number |
182004-65-5 |
| Molecular Formula |
C16H17N3O3S•CH3SO3H |
| Formula Weight |
427.5 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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