| SB-674042 |
| (S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone |
| (CAS 483313-22-0) |
 |
| Description： |
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
IC50 value: 3.76 nM (Kd)
Target: OX1 receptor
SB-674042 has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.
|
| Product No. |
KT20320 |
| Product Name |
SB-674042 |
| Synonyms |
SB 674042; SB674042 |
| Formal Name |
(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone |
| CAS Number |
483313-22-0 |
| Molecular Formula |
C24H21FN4O2S |
| Formula Weight |
448.51 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
Orexin Receptor
Almorexant
MK-3697
SB-334867
SB-408124
SB-674042
Suvorexant
TCS 1102
|
|
