| MK-3697 |
| N-[(5,6-Dimethoxy-2-pyridinyl)methyl]-5’-methyl-5-(2-thiazolyl)-[2,3’-bipyridine]-4-carboxamide |
| (CAS 1224846-01-8) |
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| Description： |
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.
IC50 value: 0.95 nM(Ki)
Target: Orexin 2 receptor antagonist
MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. Herein we report additional SAR studies within the “triaryl” amide 2-SORA series focused on improvements in compound stability in acidic media and time-dependent inhibition of CYP3A4. MK-3697 has improved stability and TDI profiles as well as excellent sleep efficacy across species.
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| Product No. |
KT20315 |
| Product Name |
MK-3697 |
| Synonyms |
MK 3697; MK3697 |
| Formal Name |
N-[(5,6-Dimethoxy-2-pyridinyl)methyl]-5’-methyl-5-(2-thiazolyl)-[2,3’-bipyridine]-4-carboxamide |
| CAS Number |
1224846-01-8 |
| Molecular Formula |
C23H21N5O3S |
| Formula Weight |
447.51 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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