Tel:+86-21-51950625 51950635
Email us at sales@koutingchina.com
   
Products
Ziprasidone 
5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
(CAS 146939-27-7)
Description:

Ziprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
IC50 value:
Target: 5-HT receptor; Dopamine receptor
Ziprasidone possesses an in vitro 5-HT2A/dopamine D2 receptor affinity ratio higher than any clinically available antipsychotic agent. In vivo, ziprasidone antagonizes 5-HT2A receptor-induced head twitch with 6-fold higher potency than for blockade of d-amphetamine-induced hyperactivity, a measure of central dopamine D2 receptor antagonism. Ziprasidone also has high affinity for the 5-HT1A, 5-HT1D and 5-HT2C receptor subtypes, which may further enhance its therapeutic potential. Ziprasidone sulfoxide and sulfone were the major metabolites in human serum. The affinities of the sulfoxide and sulfone metabolites for 5-HT2 and D2 receptors are low with respect to ziprasidone, and are thus unlikely to contribute to its antipsychotic effects. Ziprasidone was associated with significant differential adverse effects relative to placebo in BPM, BPD, and schizophrenia with no significant difference in weight gain in all 3 groups. Self-reported somnolence was increased across the 3 conditions. Subjects with BPM were more vulnerable to EPS than those with BPD or schizophrenia.
Clinical indications: Bipolar I disorder; Bipolar disorder; Mania; Schizophrenia
FDA Approved Date: February 2001

 

Product No. KT20309 
Product Name Ziprasidone 
Synonyms Geodon; CP 88059; CP-88059; CP88059
Formal Name 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one
CAS Number 146939-27-7
Molecular Formula C21H21ClN4OS
Formula Weight 412.94
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
Price & Availability In Stock. Price Negotiated.
 
Not found? Pls contact with us for sourcing service.
Our contact email:sales@koutingchina.com
 
 
 
 
Related Products:

5-HT Receptor
Setiptiline
Sumatriptan succinate
Tandospirone
Tianeptine
Tianeptine sodium
Trazodone
Tropisetron
Urapidil
Venlafaxine
Vilazodone
Vortioxetine
WAY-100635
Ziprasidone
Zolmitriptan

Order the product  * is required
Product:*
Your Name:*
Your Company:*
Add:
Tel:
Fax:
Web:
E-Mail:*
Your Demand :*

Products are for research use only. Not for human use. We do not sell to patients.
Copyrigh ©2009,China Kouting Group Limited All Rights Reserved. Supported by hxchem.net


products
Customer Service
Why Choose Us?
How to Order
How to Ship
How to Return
Frequently Asked Questions
Terms and Conditions
Email:sales@koutingchina.com
Skype: Notice