| JNJ 7777120 |
| (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone |
| (CAS 459168-41-3) |
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| Description： |
JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors. Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters. JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.). It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.
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| Product No. |
KT00466 |
| Product Name |
JNJ 7777120 |
| Synonyms |
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| Formal Name |
(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone |
| CAS Number |
459168-41-3 |
| Molecular Formula |
C14H16ClN3O |
| Formula Weight |
277.8 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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