SB408124 |
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N’-[4-(dimethylamino)phenyl]urea |
(CAS 288150-92-5) |
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Description: |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
SB408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. A recent study indicates that pretreatment of primary cultures of rat astrocytes with SB401824 before Orexin A administration significantly reduced the stimulatory action of Orexin A on both basal and forskolin-acivated cAMP production.
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Product No. |
KT00805 |
Product Name |
SB408124 |
Synonyms |
SB-408124;SB 408124 |
Formal Name |
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N’-[4-(dimethylamino)phenyl]urea |
CAS Number |
288150-92-5 |
Molecular Formula |
C19H18F2N4O |
Formula Weight |
356.37 |
Formulation |
A crystalline solid |
Purity |
98%min |
Stability |
2 years |
Storage |
-20°C |
Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
Price & Availability |
In Stock. Price Negotiated. |
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