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SB408124 
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N’-[4-(dimethylamino)phenyl]urea
(CAS 288150-92-5)
Description:

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

SB408124 binds hypocretin type 1 receptor (HcrtR1) with pKi values of 7.57. Calcium mobilization studies shows that SB408124 is a functional antagonist of the OX1 receptor with a affinity of approximately 50-fold selectivity over the OX2 receptor. A recent study indicates that pretreatment of primary cultures of rat astrocytes with SB401824 before Orexin A administration significantly reduced the stimulatory action of Orexin A on both basal and forskolin-acivated cAMP production.

 

Product No. KT00805 
Product Name SB408124 
Synonyms SB-408124;SB 408124
Formal Name N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N’-[4-(dimethylamino)phenyl]urea
CAS Number 288150-92-5
Molecular Formula C19H18F2N4O
Formula Weight 356.37
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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