| ICG-001 |
|
| (CAS 780757-88-2) |
 |
| Description： |
ICG-001 is a selective Wnt/-catenin signalling inhibitor with an IC50 of 3M. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 rescues defects in neuronal differentiation and reverse pulmonary fibrosis. ICG-001 also suppressed the interaction between CREB and -catenin.
|
| Product No. |
KT00439 |
| Product Name |
ICG-001 |
| Synonyms |
|
| Formal Name |
|
| CAS Number |
780757-88-2 |
| Molecular Formula |
C33H32N4O4 |
| Formula Weight |
548.63 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
LGK-974
IWP-2
IWP-L6
XAV-939
IWR-1-endo
KY02111
Wnt-C59 (C59)
|
|
