| SB 742457 |
| 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline |
| (CAS 607742-69-8) |
 |
| Description： |
SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.
IC50 Value: 9.63 (pKi)
Target: 5-HT6 Receptor
SB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB-742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease.
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| Product No. |
KT20293 |
| Product Name |
SB 742457 |
| Synonyms |
GSK-742457; SB742457; SB 742457; GSK742457; GSK 742457 |
| Formal Name |
3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline |
| CAS Number |
607742-69-8 |
| Molecular Formula |
C19H19N3O2S |
| Formula Weight |
353.44 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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