| Prucalopride |
| 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide |
| (CAS 179474-81-8) |
 |
| Description： |
Prucalopride (R093877) is a drug acting as a selective, high affinity 5-HT4 receptor agonist(pKi=8.6/8.1 for 5-HT4a/4b); >150-fold higher affinity for 5-HT4 receptors than for other receptors.
IC50 value: 8.6/8.1 for 5-HT4a/4b(pKi)
Target: 5-HT4 receptor
Prucalopride is a novel enterokinetic compound and is the first representative of the benzofuran class. Receptor binding data have demonstrated prucalopride's high affinity to both investigated 5-HT(4) receptor isoforms, with mean pK(i) estimates of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively. From the 50 other binding assays investigated in this study only the human D(4) receptor (pK(i) 5.63), the mouse 5-HT(3) receptor (pK(i) 5.41) and the human sigma(1) (pK(i) 5.43) have shown measurable affinity, resulting in at least 290-fold selectivity for the 5-HT(4) receptor.
|
| Product No. |
KT20278 |
| Product Name |
Prucalopride |
| Synonyms |
Resolor; Resotran |
| Formal Name |
4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide |
| CAS Number |
179474-81-8 |
| Molecular Formula |
C18H26ClN3O3 |
| Formula Weight |
367.87 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
5-HT Receptor
PRX-08066
Quetiapine
Ramosetron
Risperidone
Rizatriptan benzoate
RS 127445
RU 24969
Sarpogrelate
SB 271046
SB 269970
SB 742457
Sertraline
|
|
