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GW5074 
3-​[(3,​5-​dibromo-​4-​hydroxyphenyl)methylene]-​1,​3-​dihydro-​5-​iodo-​2H-​indol-​2-​one
(CAS 220904-83-6)
Description:

Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.3 GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.

 

Product No. KT00416 
Product Name GW5074 
Synonyms
Formal Name 3-​[(3,​5-​dibromo-​4-​hydroxyphenyl)methylene]-​1,​3-​dihydro-​5-​iodo-​2H-​indol-​2-​one
CAS Number 220904-83-6
Molecular Formula C15H8Br2INO2
Formula Weight 520.9
Formulation A crystalline solid
Purity 98%min
Stability 2 years
Storage -20°C
Shipping USD45 for Europe and USA. No shipping charge once amount reach USD500
Quality Control HNMR,CNMR,LCMS,HPLC,IR,etc.
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