| GW5074 |
| 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one |
| (CAS 220904-83-6) |
 |
| Description： |
Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks phosphorylation of ERK1/2 by 90% in cells stimulated with epidermal growth factor when given at 5 µM.3 GW 5074 shows more than 100-fold selectivity for Raf-1 versus several related kinases.
|
| Product No. |
KT00416 |
| Product Name |
GW5074 |
| Synonyms |
|
| Formal Name |
3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one |
| CAS Number |
220904-83-6 |
| Molecular Formula |
C15H8Br2INO2 |
| Formula Weight |
520.9 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
|
| Related Products： |
AZ 628
B-Raf IN 1
B-Raf inhibitor
BRAF inhibitor
CEP-32496
Dabrafenib
GDC-0879
HG6-64-1
LGX818
MLN 2480
PLX-4720
RAF265
SB-590885
|
|
