| SN-38 |
| 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| (CAS 86639-52-3) |
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| Description： |
SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
SN-38 is the active metabolite of irinotecan (Item No. 14180), a derivative of the alkaloid camptothecin (Item No. 11694), and acts as a potent inhibitor of DNA topoisomerase I.It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1.SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).
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| Product No. |
KT00837 |
| Product Name |
SN-38 |
| Synonyms |
7-Ethyl-10-hydroxycamptothecin;NK 012 |
| Formal Name |
4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| CAS Number |
86639-52-3 |
| Molecular Formula |
C22H20N2O5 |
| Formula Weight |
392.40 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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| Related Products： |
Irinotecan (hydrochloride)
Topotecan (hydrochloride)
Voreloxin
Nexturastat A
RG2833 (RGFP109)
Doxorubicin (Adriamycin)
Etoposide
Camptothecin
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