| Pixantrone dimaleate |
| 6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione (2Z)-2-butenedioate (1:2) |
| (CAS 144675-97-8) |
 |
| Description： |
Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.
Target: Others
Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines. An in vitro crosslinking assay demonstrated that Pixantrone is efficiently activated by formaldehyde to generate covalent drug-DNA adducts capable of stabilizing double-stranded DNA in denaturing conditions. Pixantrone-DNA adduct formation is both concentration and time dependent and the reaction exhibits an absolute requirement for formaldehyde. Pixantrone exhibited a 10- to 100-fold greater propensity to generate adducts at equimolar formaldehyde and drug concentrations. Pixantrone-DNA adducts are thermally and temporally labile, yet they exhibit a greater thermal midpoint temperature and an extended half-life at 37 degrees C when compared to mitoxantrone-DNA adducts.
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| Product No. |
KT20038 |
| Product Name |
Pixantrone dimaleate |
| Synonyms |
BBR2778 dimaleate; BBR 2778 dimaleate; BBR-2778 dimaleate |
| Formal Name |
6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione (2Z)-2-butenedioate (1:2) |
| CAS Number |
144675-97-8 |
| Molecular Formula |
C17H19N5O2.2(C4H4O4) |
| Formula Weight |
557.52 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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