| DMXAA |
| 5,6-Dimethylxantheonone-4-acetic acid |
| (CAS 117570-53-3) |
 |
| Description： |
DMXAA is a xanthene which acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC50 = 119 and 11 µM, respectively).
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| Product No. |
KT20037 |
| Product Name |
DMXAA |
| Synonyms |
NSC 640488;Vadimezan;ASA 404 |
| Formal Name |
5,6-Dimethylxantheonone-4-acetic acid |
| CAS Number |
117570-53-3 |
| Molecular Formula |
C17H14O4 |
| Formula Weight |
282.29 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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