| STF-62247 |
| N-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine |
| (CAS 315702-99-9) |
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| Description： |
STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM).
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| Product No. |
KT00857 |
| Product Name |
STF-62247 |
| Synonyms |
STF62247；STF 62247 |
| Formal Name |
N-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine |
| CAS Number |
315702-99-9 |
| Molecular Formula |
C15H13N3S |
| Formula Weight |
267.35 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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