Mirtazapine |
(RS)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino-[2,1-a]pyrido[2,3-c][2]benzazepine |
(CAS 85650-52-8) |
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Description: |
Mirtazapine is a potent tetracyclic antidepressant.
Target: 5-HT Receptor
Mirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors.Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex.
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Product No. |
KT20262 |
Product Name |
Mirtazapine |
Synonyms |
Remeron; SolTab; Zispin; Org3770; 6-Azamianserin; Avanza |
Formal Name |
(RS)-1,2,3,4,10,14b-Hexahydro-2-methylpyrazino-[2,1-a]pyrido[2,3-c][2]benzazepine |
CAS Number |
85650-52-8 |
Molecular Formula |
C17H19N3 |
Formula Weight |
265.35 |
Formulation |
A crystalline solid |
Purity |
98%min |
Stability |
2 years |
Storage |
-20°C |
Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
Price & Availability |
In Stock. Price Negotiated. |
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