| Bexarotene |
| 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)-benzoic acid |
| (CAS 153559-49-0) |
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| Description： |
Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50 = 28, 25, and 20 nM for RXRα, β, and γ, respectively). It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer. Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.
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| Product No. |
KT20033 |
| Product Name |
Bexarotene |
| Synonyms |
LG 100069; Targretin; Ro 26-4455; SR 11247; LGD 1069 |
| Formal Name |
4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)-benzoic acid |
| CAS Number |
153559-49-0 |
| Molecular Formula |
C24H28O2 |
| Formula Weight |
348.5 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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AGN 205327
AGN 205728
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