| SU11274 |
| N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide |
| (CAS 658084-23-2) |
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| Description： |
SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.Dysregulation of c-Met occurs in a many types of cancer.SU 11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).It has much less or no activity against other receptor tyrosine kinases.SU 11274 induces apoptosis and cell cycle arrest in transformed BaF3 cells and cancer cell lines.
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| Product No. |
KT00860 |
| Product Name |
SU11274 |
| Synonyms |
Met Kinase Inhibitor;PKI-SU11274 |
| Formal Name |
N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide |
| CAS Number |
658084-23-2 |
| Molecular Formula |
C28H30ClN5O4S |
| Formula Weight |
568.09 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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