| Alverine citrate |
| N-Ethyl-3,3’-diphenyldipropylamine citrate |
| (CAS 5560-59-8) |
 |
| Description： |
Alverine Citrate(NSC35459) is a drug used for functional gastrointestinal disorders.
Target: 5-HT Receptor
Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg kg(-1)) suppressed the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 microg/rat) alverine citrate reduced 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies revealed that alverine citrate had a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes . Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+ .
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| Product No. |
KT20119 |
| Product Name |
Alverine citrate |
| Synonyms |
Spasmonal; NSC 35459; NSC35459; NSC-35459 |
| Formal Name |
N-Ethyl-3,3’-diphenyldipropylamine citrate |
| CAS Number |
5560-59-8 |
| Molecular Formula |
C26H35NO7 |
| Formula Weight |
473.56 |
| Formulation |
A crystalline solid |
| Purity |
98%min |
| Stability |
2 years |
| Storage |
-20°C |
| Shipping |
USD45 for Europe and USA. No shipping charge once amount reach USD500 |
| Quality Control |
HNMR,CNMR,LCMS,HPLC,IR,etc. |
| Price & Availability |
In Stock. Price Negotiated. |
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